Curriculum Vitae

Isabella Julia Elisabeth HEUSER

Studium

Nov. 1982	Drittes Staatsexamen in Humanmedizin
1981 - 1982	Praktisches Jahr in den Städtischen Kliniken Darmstadt (Wahlfach: Neurologie)
12.7.1979	Diplom in Psychologie
1976 – 1981	Studium der Humanmedizin an der Universität Mainz
1973 – 1979	Studium der Psychologie an der Universität Mainz

Beruflicher Werdegang

seit 17.04.2001	Direktorin der Klinik und Hochschulambulanz für Psychiatrie und Psychotherapie der Charité - Universitätsmedizin Berlin, Campus Benjamin Franklin
07/97 – 03/01	C3-Professur für Psychiatrie und Psychotherapie der Universität Heidelberg
04/96 – 03/01	Leiterin der Gedächtnissprechstunde und des Schlaflabors am Zentralinstitut für Seelische Gesundheit Mannheim
04/96 – 03/01	Leiterin der Arbeitsgruppe „Depression, Demenz, Altern“ am Zentralinstitut für Seelische Gesundheit Mannheim
04/96 – 03/01	Leitende Oberärztin der Klinik für Psychiatrie und Psychotherapie am Zentralinstitut für Seelische Gesundheit Mannheim
Mai 1994	Habilitation und Venia legendi im Fach Psychiatrie an der Ludwig-Maximilians-Universität, München
01/92 – 02/96	Leiterin der Gedächtnisambulanz am Max-Planck-Institut für Psychiatrie, München
01/90 – 02/96	Leiterin der Arbeitsgruppe „Depression und stressbezogene Erkrankungen“ am Max-Planck-Institut für Psychiatrie, München
01/90 – 02/96	Oberärztin am Max-Planck-Institut für Psychiatrie, Klinisches Institut, München
08/88 – 12/89	Oberärztin an der Psychiatrischen Universitätsklinik Freiburg
07/86 – 08/88	Fogarty-Stipendiatin an der Experimental Therapeutics Branch des Neurologischen Instituts der National Institutes of Health, Bethesda, Maryland, USA
12/82 – 05/86	Facharztausbildung an der Psychiatrischen Universitätsklinik Mainz

Mitgliedschaften

Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie (AGNP)
Deutsche Ärztinnenbund e.V.
Deutsche Gesellschaft für Alternsforschung e.V.
Deutsche Gesellschaft für Biologische Psychiatrie (DGBP)
Deutsche Gesellschaft für Endokrinologie
Deutsche Gesellschaft für Geriatrie e. V.
Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde (DGPPN)
Deutsche Gesellschaft für Schlafforschung und Schlafmedizin
Neurowissenschaftliche Gesellschaft e.V.
Hirnliga e.V.(Mitglied des erweiterten Vorstandes)
European College of Neuropsychopharmacology (ECNP)
American Psychiatric Association (APA)
International Psychogeriatric Asssociation (IPA)
International Society of Psychoneuroendocrinology (ISPNE)
Society of Biological Psychiatry
The International Neuropeptide Society
The New York Academy of Sciences

Weitere berufliche Aktivitäten

seit 2008	Präsident der Society of Psychoneuroendocrinology (ISPNE)
seit 2007	Board Member des Exzellenzclusters “Languages of Emotion”, Freie Universität Berlin
seit 2006	Faculty Member der "Berlin Graduate School Mind and Brain"
seit 2004	Section Editor „Psychiatry“ der Zeitschrift „Experimental Neurology“
seit 1998	Editorial Board Mitglied der Zeitschrift „Psychoneuroendocrinology“
seit 12/96	Editorial Board Mitglied der Zeitschrift „Psychiatric Research“
04/01 - 09/08	1. Sprecherin des DFG-Graduiertenkolleg „Neuropsychiatrie und Psychologie des Alters“
	Homepage: www.fu-berlin.de/age
seit 2001	Vorstandsmitglied des Kompetenznetz „Demenzen“
seit 2001	Mitglied im Kompetenznetz „Schizophrenie“
seit 2000	Mitglied im Kompetenznetz „Depression“

Preise

2007	Hildegard Hampp Preis für Gerontopsychiatrie
2004	Verleihung der Boerhaave-Professur der Universität Leiden, Niederlande
1997	Internationaler „ANNA-MONIKA-PREIS“ für Depressionsforschung

Publikationen

Erstautor

Heuser I, Kuehl K-P (2007) Mild cognitive impairment (MCI), concepts, diagnostic and therapeutic approaches. Die Psychiatrie 4:20-32
Heuser I, Dettling M (2004) Medizinische Versorgung und therapeutische Optionen unter gesundheitsökonomischen Aspekten bei psychiatrischen Patienten in Deutschland am Beispiel schizophrener und depressiver Störungen. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 47:745-50
Heuser I (2003) Prevention of dementias: state of the art. Dtsch Med Wochenschr 128:421-2
Heuser I (2003) Depression: Ein kardialer Risikofaktor. DNP 4:36-7
Heuser I (2003) MCI Combi: Die aktuelle Therapiestudie im Kompetenznetz Demenzen. Psychoneuro 29:16-7
Heuser I, Lammers C (2003) Stress and the brain. Neurobiol Aging 24 Suppl 1:S69-76
Heuser I, Reischies F (2002) Die Altersdepression erkennen und behandeln. Extracta Geriatrica 1:10-4
Heuser I (2002) Depression, endocrinologically a syndrome of premature aging? Maturitas 41 Suppl 1:S19-23
Heuser I (2002) Therapeutische Strategien bei Demenz. Neuro Psych Nachrichten Juli 2002, S. 13
Heuser I (2001) Demenzen: Medikamentöse Therapie - aktueller Stand und Ausblick. Notabene Medici 7:294
Heuser I, Deuschle M, Weber A, Kniest A, Ziegler C, Weber B, Colla M (2000) The role of mineralocorticoid receptors upon the circadian activity of the human hypothalamus-pituitary-adrenal system: effect of age. Neurobiol Aging 21:585-9
Heuser I, Deuschle M, Weber B, Stalla GK, Holsboer F (2000) Increased activity of the hypothalamus-pituitary-adrenal system after treatment with the mineralcorticoid receptor antagonist spironolactone. Psychoneuro-endocrinology 25:513-8
Heuser I, Hartmann A, Oertel H (1999) Androgen Replacement in a 48, XXYY-Male. Arch Gen Psychiatry 56:194-5
Heuser I, Bissette G, Dettling M, Schweiger U, Gotthardt U, Schmider J, Lammers C.-H., Nemeroff C.B., Holsboer F (1998) Cerebrospinal fluid concentrations of corticotropin-releasing hormone, vasopressin, and somatostatin in depressed patients and healthy controls: Response to amitriptyline treatment. Depression and Anxiety 8:71-9
Heuser I (1998) The Hypothalamic-Pituitary-Adrenal System in Depression. Pharmacopsychiat. 31:10-3
Heuser I, Deuschle M, Luppa P, Schweiger U, Standhardt H, Weber B (1998) Increased diurnal plasma concentrations of dehydroepiandrosterone (DHEA) in depressed patients. J Clin Endocrinol Metab 83:3130-3
Heuser I (1997) The HPA-system in late-life depression. Aging 9:40-1
Heuser I (1996) Gedächtnisstörungen. Der Internist 37 (11/96) Weiterbildung 1189-202
Heuser I, Schweiger U, Gotthardt U, Schmider J, Lammers C-H, Dettling M, Holsboer F (1996) Pituitary-adrenal-system regulation and psychopathology during amitriptyline treatment in elderly depressed patients and in normal controls. Am J Psychiatry 153:93-9
Heuser I (1995) Psychiatrische Notfallsituationen: psychomotorischer Stupor. Editorial. Münch med Wschr 137:30/216
Heuser I (1995) Adipositas ade? Editorial. Münch med Wschr 137:36/565
Heuser IJ (1994) Psychiatrische Patienten: Veränderte Glukokortikoidregulation ist nosologisch unspezifisch. Fortschr Med 1-2:31
Heuser I (1994) Psychiatrische Notfallsituationen: psychomotorische Erregungszustände. Editorial. Münch med Wschr 136:618/34-619/37
Heuser IJ, Gotthardt U, Schweiger U, Schmider J, Lammers C-H, Dettling M, Holsboer F (1994) Age-associated changes of pituitary-adrenocortical hormone regulation in humans: importance of gender. Neurobiol Aging 15:227-31
Heuser I, Yassouridis A, Holsboer F (1994) The combined dexamethasone/CRH-test: A refined laboratory test for psychiatric disorders. J Psychiatr Res 28:341-56
Heuser I, Heuser-Link M, Gotthardt U, Grasser A, Holsboer F (1993) Behavioral effects of a synthetic ACTH4-9 analog in patients with depression and patients with Alzheimer's disease. J Clin Psychopharmacol 13:171-4
Heuser IJ, Holsboer F (1992) The CRH-stimulation test in affective and anxiety disorder: comparison to physical stress. Clinical Neuropharmacology 15: 159A-60A
Heuser IJ, Baronti F, Marin CA, Ma N, Merriam GR, Chase TN, Mouradian MM (1992) Growth hormone secretion in Alzheimer's disease: 24-hour profile of basal levels and response to stimulation and suppression studies. Neurobiol Aging 13:255-60
Heuser I (1991) Diagnostik und Erstversorgung von Patienten mit akuten psychiatrischen Erkrankungen, Teil 1. Notfallmedizin 16:82-92
Heuser IJ (1991) Diagnostik und Erstversorgung von Patienten mit akuten psychiatrischen Erkrankungen, Teil 2. Notfallmedizin 17:142-6
Heuser IJ, Chase TN, Mouradian MM (1991) The limbic-hypothalamic-pituitary-adrenal-axis in Huntington's disease. Biol Psychiatry 30:943-52
Heuser IJ, Grasser A, Gotthardt U, Schmider J, Holsboer F (1991) Psychopathological, cognitive and neuroendocrine responses to treatment with amitriptyline in elderly depressed patients. Eur Neuropsychopharmacol 1:327-8
Heuser IJ, Holsboer F (1991) Research activity at the Max Planck Institute for Psychiatry (Munich): Depression in later life. Int Psychogeriatrics 3:75-8
Heuser IJE, Wark H-J, Keul J, Holsboer F (1991) Hypothalamic-pituitary-adrenal axis function in elderly endurance athletes. J Clin Endocrinol Metab 73:485-8
Heuser IJ, Juncos JL, Gold PW (1989) Neuroendocrine functions in Alzheimer's disease patients. J Neural Transm 1:76
Heuser IJ, von Bardeleben U, Holsboer F (1988) Response of ACTH and cortisol to human CRH after short-term abstention from alcohol abuse. Biol Psychiatry 24:316-21
Heuser I, Benkert O (1986) Lorazepam for a short-term alleviation of mutism. J Clin Psychopharmacol 6:62

Seniorautor

Klusmann V, Evers A, Schwarzer R, Schlattmann P, Reischies FM, Heuser I*, Dimeo FC* (2010) Complex mental and physical activity in older women and cognitive performance: A 6-month randomized controlled trial. J Gerontol. A Biol Sci Med Sci 65:680-88 (*geteilte Letzautorschaft)
Repantis D, Laisney O, Heuser I (2010) Acetylcholinesterase inhibitors and memantine for neuroenhancement in healthy individuals: A systematic review. Pharmacological Research Mar 1 (Epub)
Bajbouj M, Merkl A, Schlaepfer TE, Frick C, Zobel A, Maier W, O’Keane V, Corcoran, Adolfsson R, Trimble M, Rau H, Hoff H-J, Padberg F, Müller-Siecheneder, Audenaert K, Van den Abbeele D, Matthews K, Christmas D, Eljamel S, Heuser I (2010). Two-year outcome of Vagus Nerve Stimulation (VNS) in treatment-resistant depression. J Clin Psychopharmacol 30:273-81
Bajbouj M, Heuser I (2009) Stimulating the brain to treat depression. Exp Neurol 219:1
Repantis D, Schlattmann P, Laisney O, Heuser I (2009) Antidepressants for neuroenhancement in healthy individuals: a systematic review. Poiesis & Praxis 6:139-74
Hornung OP, Regen F, Dorn H, Anghelescu I, Kathmann N, Schredl M, Danker-Hopfe H, Heuser I (2009) The effects of donepezil on postlearning sleep EEG of healthy older adults. Pharmacopsychiatry 42:9-13
Colla M, Schubert F, Bubner M, Heidenreich JO, Bajbouj M, Seifert F, Luborzewski A, Heuser I*, Kronenberg G* (2009) Glutamate as a spectroscopic marker of hippocampal structural plasticity is elevated in long-term euthymic bipolar patients on chronic lithium therapy and correlates inversely with diurnal cortisol. Mol Psychiatry 14:696-704 *geteilte Letzt-Autorschaft
Anghelescu I, Heuser I (2007) Acetylcholinesterase inhibitors for dementia - an update. MMW Fortschr Med 149 Suppl 2:76-8
Colla M, Ende G, Alm B, Henn F, Heuser I. Cognitive inhibition processing is associated with markers of membrane metabolism in the dorsal anterior cingulated cortex: an in vivo (1)H-MRSI study of Continous Performance Test in ADHD in adults and control. (submitted)
Hornung OP, Regen F, Danker-Hopfe H, Schredl M, Heuser I (2007) The relationship between REM sleep and memory consolidation in old age and effects of cholinergic medication. Biol Psychiatry 61:750-7
Colla M, Kronenberg G, Deuschle M, Meichel K, Hagen T, Bohrer M, Heuser I (2007) Hippocampal volume reduction and HPA-system activity in major depression. J Psychiatr Res 41:553-60
Danker-Hopfe H, Hornung O, Regen F, Hansen ML, Albrecht N, Heuser I (2006) Subjective sleep quality in noncomplaining elderly subjects: rsults of a follow-up study. Anthropol Anz 64:369-76
Weber-Hamann B, Werner M, Hentschel F, Bindeballe N, Lederbogen F, Deuschle M, Heuser I (2006) Metabolic changes in elderly patients with major depression: evidence for increased accumulation of visceral fat at follow-up. Psychoneuroendocrinology 31:347-54
Bajbouj M, Luborzewski A, Heuser I (2006) Stimulationsverfahren zur Behandlung von Depressionen. Neuroforum 12:184-9
Schredl M, Hornung O, Regen F, Albrecht N, Danker-Hopfe H, Heuser I (2006) The effect of donepezil on sleep in elderly, healthy persons: a double-blind placebo-controlled study. Pharmacopsychiatry 39:205-8
Kronenberg G, Berger P, Tauber R, Bandelow B, Henkel V, Heuser I (2005) Randomized, double-blind study of SR142801 (Osanetant). A novel neurokinin-3 (NK3) receptor antagonist in panic disorder with pre- and posttreatment cholecystokinin tetrapeptide (CKK-4) challenges. Pharmacopsychiatry 38:24-9
Bajbouj M, Heuser I (2005) Antidepressive Stimulationsverfahren. Nervenarzt 76:28-35
Bajbouj M, Lang UE, Neu P, Heuser I (2005) Therapeutic brain stimulation and cortical excitability in depressed patients. Am J Psychiatry 162:2192-3
Ziegenhorn A, Heuser I (2005) Die leichte kognitive Störung oder: Ist Vergesslichkeit im Alter nicht normal? Neurotransmitter 1:60-4
Hornung OP, Danker-Hopfe H, Heuser I (2005) Age-related changes in sleep and memory: commonalities and interrelationships. Exp Gerontol 40:279-85
Deuschle M, Kniest A, Niemann H, Erb-Bies N, Colla M, Hamann B, Heuser I (2004) Impaired declarative memory in depressed patients is slow to recover: clinical experience. Pharmacopsychiatry 37:147-51
Niedermaier N, Bohrer E, Schulte K, Schlattmann P, Heuser I (2004) Prevention and treatment of poststroke depression with mirtazapine in patients with acute stroke. J Clin Psychiatry 65:1619-23
Deuschle M, Krumm B, Bindeballe N, Colla M, Hamann B, Lederbogen F, Gilles M, Heuser I (2004) Open-label non-randomized versus double-blind randomized antidepressive treatment: what are the advantages of clinical decision over randomization? Pharmacopsychiatry 37:299-302
Godemann F, Koffroth C, Neu P, Heuser I (2004) Why does vertigo become chronic after neuropathia vestibularis? Psychosom Med 66:783-7
Deuschle M, Luppa P, Gilles M, Hamann B, Heuser I (2004) Antidepressant treatment and dehydroepidandrosterone sulfate: different effects of amitriptyline and paroxetine. Neuropsychobiology 50:252-6
Deuschle M, Luppa P, Hamann B, Nonell A, Heuser I (2003) Increased concentra-tion of corticosteroid-binding globulin due to antidepressant treatment with amitriptyline, but not paroxetine. J Psychiatr Res 37:85-7
Deuschle M, Hamann B, Meichel C, Krumm B, Lederbogen F, Kniest A, Colla M, Heuser I (2003) Antidepressive treatment with amitriptyline and paroxetine: effects upon saliva cortisol concentrations. J Clin Psychopharmacol 23:201-5
Deuschle M, Lecei O, Stalla GK, Landgraf R, Hamann B, Lederbogen F, Uhr M, Luppa P, Maras A, Colla M, Heuser I (2003) Steroid synthesis inhibition with ketoconazole and its effect upon the regulation of the hypothalamus-pituitary-adrenal system in healthy humans. Neuropsychopharmacology 28:379-83
Colla M, Ende G, Bohrer M, Deuschle M, Kronenberg G, Henn F, Heuser I (2003) MR spectroscopy in Alzheimer’s disease: gender differences in probabilistic learning capacity. Neurobiol Aging 24:545-52
Deuschle M, Bode L, Schnitzler P, Meyding-Lamadé U, Plesch A, Ludwig H, Hamann B, Heuser I (2003) Hypothalamic-pituaitary-adrenal (HPA) system activity in depression and infection with Borna disease virus and Chlamydia pneumoniae. Mol Psychiatry 8:469-70
Weber-Hamann B, Hentschel F, Kniest A, Deuschle M, Colla M, Lederbogen F, Heuser I (2002) Hypercortisolemic depression is associated with increased intra-abdominal fat. Psychosom Med 64:274-7
Schredl M, Kronenberg G, Nonell P, Heuser I (2002) Sleep quality in patients with panic disorder: relationship to nocturnal panic attacks. Somnologie 6:149-53
Kronenberg G, Schredl M, Fiedler K, Heuser I (2001) In healthy volunteers responses to challenge with cholecystokinin tetrapeptide differ between administration during REM and delta sleep. Depress Anxiety 14:141-4
Schredl M, Weber B, Leins M-L, Heuser I (2001) Donepezil-induces REM sleep augmentation enhances memory performance in elderly, healthy persons. Exp Gerontol 36:353-61
Schredl M, Kronenberg G, Nonnell P, Heuser I (2001) Dream recall, nightmare frequency, and nocturnal panic attacks in patients with panic disorder. J Nerv Ment Dis 189:559-62
Schredl M, Weber B, Braus D, Heuser I (2000) The effect of rivastigmine on sleep in elderly healthy subjects. Exp Gerontol 35:243-9
Schweiger U, Weber B, Deuschle M, Heuser I (2000) Lumbar bone mineral density in patients with major depression: evidence of increased bone loss at follow-up. Am J Psychiatry 157:118-20
Weber B, Schweiger U, Deuschle M, Heuser I (2000) Major depression and impaired glucose tolerance. Exp Clin Endocrinol Diabetes 108:187-90
Weber B, Lewicka S, Deuschle M, Colla M, Vecsei P, Heuser I (2000) Increased diurnal plasma concentrations of cortisone in depressed patients. J Clin Endocrinol Metab 85:1133-6
Weber B, Lewicka S, Deuschle M, Colla M, Heuser I (2000) Testosterone, androstenedione and dihydrotestosterone concentrations are elevated in female patients with major depression. Psychoneuroendocrinology 25:765-71
Lammers C-H, Deuschle M, Weigmann H, Härtter S, Hiemke C, Heese C, Heuser I (1999) Coadministration of clozapine and fluvoxamine in psychotic patients - clinical experiences. Pharmacopsychiatry 2:76-7
Lederbogen F, Deuschle M, Heuser I (1999) Depression: ein kardiovaskulärer Risikofaktor? Internist 40:1119-21
Schmider J, Standhardt H, Deuschle M, Drancoli J, Heuser I (1999) A double blind comparison of lorazepam and oxazepam in psychomotor retardation and mutism. Biol Psychiatry 46:437-41
Schredl M, Kraft-Schneider B, Kröger H, Heuser I (1999) Dream content of patients with sleep apnea. Somnologie 3:319-23
Schweiger U, Deuschle M, Weber B, Körner A, Lammers C-H, Schmider J, Gotthardt U, Heuser I (1999) Testosterone, gonadotropin and cortisol secretion in male patients with major depression. Psychosomatic Med 61:292-6
Deuschle M, Schweiger U, Gotthardt U, Weber B, Körner A, Schmider J, Standhardt H, Lammers C-H, Krumm B, Heuser I (1998) The combined dexamethasone/CRH-stimulation test is more closely associated with features of diurnal activity of the hypothalamo-pituitary-adrenal system than the dexamethasone suppression test. Biol Psychiatry 43:762-6
Deuschle M, Weber B, Colla M, Depner M, Heuser I (1998) Effects of major depression, aging and gender upon calculated diurnal free plasma cortisol concentrations: a re-evaluation study. Stress 2:281-7
Deuschle M, Weber B, Colla M, Müller M, Kniest A, Heuser I (1998) Mineralocorticoid receptor modulates basal activity of hypothalamus-pituitary-adrenocortical system also in humans. Neuroendocrinology 223:1-6
Deuschle M, Weber B, Standhardt H, Lammers C-H, Hartmann A, Heuser I (1998) Nortriptyline Pulse Loading in Depressed Patients. J Clin Psychopharmacol 18:96-7
Schredl M, Schäfer G, Weber B, Heuser I (1998) Dreaming and insomnia: Dream recall and dream content of patients with insomnia. J Sleep Res 7:191-8
Schredl M, Schenck W, Görtelmeyer R, Heuser I (1998) Einflussfaktoren auf die Schlafqualität bei Gesunden. Somnologie 2:99-103
Schredl M, Weber B, Heuser I (1998) REM-Schlaf und Gedächtnis. Psychologische Beiträge, Band 40:340-9.
Deuschle M, Blum WF, Frystyk J, Ørskov H, Schweiger U, Weber B, Körner A, Gotthardt U, Schmider J, Standhardt H, Heuser I (1997) Endurance training and its effect upon the activity of the GH-IGFs system in the elderly. Int J Sports Med 4:249-54
Deuschle M, Blum WF, Strasburger CJ, Schweiger U, Weber B, Körner A, Standhardt H, Gotthardt U, Schmider J, Pflaum C-D, Heuser I (1997) Insulin-like growth factor I (IGF-I) plasma concentrations are increased in depressed patients. Psychoneuroendocrinology 22:493-503
Deuschle M, Gotthardt U, Schweiger U, Weber B, Körner A, Schmider J, Standhard H, Lammers C-H, Heuser I (1997) With aging in humans the activity of the hypothalamus-pituitary-adrenal system increases and its circadian rhythm flattens. Life Sci 61:2239-46
Deuschle M, Härtter S, Hiemke C, Standhardt H, Hartmann A, Heuser I (1997) Doxepin and its metabolites in plasma and cerebrospinal fluid in depressed patients. Psychopharmacology 131:19-22
Deuschle M, Schmider J, Weber B, Standhardt H, Körner A, Lammers C-H, Schweiger U, Hartmann A, Heuser I (1997) Pulse-dosing and conventional application of doxepin: Effects upon psychopathology and hypothalamus-pituitary-adrenal (HPA) system. J Clin Psychopharmacol 17:156-60
Deuschle M, Schweiger U, Standhardt H, Weber B, Heuser I (1997) Corticosteroid-binding globulin is not decreased in depressed patients. Psychoneuroendocrinology 21: 645-9
Deuschle M, Schweiger U, Weber B, Gotthardt U, Körner A, Schmider J, Standhardt H, Lammers C-H, Heuser I (1997) Diurnal activity and pulsatility of the hypothalamus-pituitary-adrenal system in male depressed patients and healthy controls. J Clin Endocrinol Metab 82:234-8
Deuschle M, Weber B, Standhardt, H, Lammers C-H, Hartman A, Heuser I (1997) Nortriptyline pulse-loading in depressed patients. J Clin Psychopharmacol 18:1-2
Hartmann A, Veldhuis J D, Deuschle M, Standhardt H, Heuser I (1997) Twenty-four hour cortisol profiles in patients with Alzheimer’s and Parkinson’s dieseases compared to normal controls; their relation to secretory pulsatility and diurnal variation. Neurobiol Aging 18:285-9
Deuschle M, Blum W, Englaro P, Schweiger U, Weber B, Pflaum C, Heuser I (1996) Plasma leptin in depressed patients and healthy controls. Horm Metab Res 28:714-7
Deuschle M, Schweiger U, Standhardt H, Weber B, Heuser I (1996) Corticosteroid-binding globulin is not decreased in depressed patients. Psychoneuroendocrinology 21:645-50
Hartmann A, Heuser I (1996) Neurosteroide - Grundlagen, Anxiolyse und klinische Anwendungsmöglichkeiten. Fortschr Neurol Psychiat 64:444-51
Lammers C-H, Heuser I (1996) Hypothalamic-pituitary-adrenal axis in schizophrenia - response. [Letter] Biol Psychiatry 40:561
Schweiger U, Heuser I (1996) Reply [Letter] Am J Psychiatry 153:140-41
Gotthardt U, Schweiger U, Fahrenberg J, Lauer Ch., Holsboer F, Heuser I (1995) Cortisol, ACTH, and cardiovascular response to a cognitive challenge paradigm in aging and depression. Am J Physiol 268:R865-R873
Hatzinger M, Z'Brun A, Hemmeter U, Baumann F, Holsboer-Trachsler E, Heuser IJ (1995) Hypothalamic-pituitary-adrenal system function in patients with Alzheimer's disease. Neurobiol Aging 16:205-9
Kellner M, Holsboer F, Heuser I (1995) Intermediate glucocorticoid feedback of corticotropin secretion in patients with major depression. Psychiatry Res 59:157-60
Lammers C-H, Garcia-Borreguero D, Schmider J, Gotthardt U, Dettling M, Holsboer F, Heuser IJE (1995) Combined dexametha-sone/corticotropin-releasing hormone test in patients with schizophrenia and in normal controls: II. Biol Psychiatry 38:803-7
Schmider J, Deuschle M, Schweiger U, Körner A, Gotthardt U, Heuser IJ (1995) Amitriptyline metabolism in elderly depressed patients and normal controls in relation to hypothalamic-pituitary-adrenal system function. J Clin Psychopharmacol 15:250-8
Schmider J, Lammers C-H, Gotthardt U, Dettling M, Holsboer F, Heuser IJE (1995) Combined dexamethasone/corticotropin-releasing hormone test in acute and remitted manic patients, in acute depression, and in normal controls: I. Biol Psychiat 38:797-802
Schweiger U, Deuschle M, Körner A, Lammers C-H, Schmider J, Gotthardt U, Holsboer F, Heuser I (1994) Low lumbar bone mineral density in patients with major depression. Am J Psychiatry 151:1691-3

Mitautor

Schennach-Wolff R, Seemüller F, Mayr A, Maier W, Klingberg S, Heuser I, Klosterkötter J, Gastpar M, Häfner H, Sauer H, Schneider F, Gaebel W, Jäger M, Möller H-J, Riedel M. Development of a valid early improvement threshold to predict response and remission in first-episode schizophrenia patients. Br J Psychiatry (in press)
Seemüller F. Do efficacy and effectiveness samples differ in outcome? J Clin Psychiatry (in press)
Gaebel W et al. Relapse prevention in first-episode schizophrenia: Maintenance vs. Intermittent drug treatment with prodrome-based early intervention. J Clin Psychiatry (in press)
Teipel SJ, Ewers M, Wolf S, Jessen F, Kölsch H, Arlt S, Luckhaus C, Schönknecht P, Schmidtke K, Heuser I, Frölich L, Ende G, Pantel J, Wiltfang J, Rakebrandt F, Peters O, Born C, Konrhuber J, Hampel H (2010) Multicentre variability of MRI-based medial temporal lobe volumetry in Alzheimer’s disease. Psychiatry Res May 19 (epub)
Paslakis G, Heuser I, Schweiger U, Deuschle M (2010) A single DEX/CRH test in male drug-free depressed patients is associated with the clinical response to treatment with fluoxetine. J Psychiatr Res May 4 (epub)
Riedel O, Klotsche J, Spottke A, Deuschl G, Förstl H, Henn F, Heuser I, Oertel W, Reichmann H, Riederer P, Trenkwalder C, Dodel R, Wittchen H-U (2010) Frequency of dementia, depression, and other neuropsychiatric symptoms in 1,449 outpatients with Parkinson’s disease. J Neurol Feb 06 (epub)
Röpke S, Schröder-Abé M, Schütz A, Jacob G, Dams A, Vater A, Rüter A, Merkl A, Heuser I; Lammers CH (2010) Dialectic behavioural therapy has an impact on self-concept clarity and facets of self-esteem in women with borderline personality disorder. Clin Psychol Psychother Feb 25 (epub)
Röpke S, Ziegenhorn A, Kronsbein J, Merkl A, Bahri S, Lange J, Lübbert H, Schweiger U, Heuser I, Lammers CH (2010) Incidence of polycystic ovaries and androgen serum levels in women with borderline personality disorders. J Psychiatr Res Feb 9 (epub)
Schennach-Wolff, Jäger M, Obermeier M, Schmauss M; Laux G, Pfeiffer H, Naber D, Schmidt LG, Gaebel W, Klosterkötter J, Heuser I, Kühnj KU, Lemke MR, Rüther E, Klingberg S, Gastpar M, Seemüller F, Möller HJ, Riedel M (2010) Quality of life and subjective well-being in schizophrenia and schizophrenia spectrum disorders: Valid predictors of symptomatic response and remission? World J Biol Psychiatry Apr 12 (epub)
Schennach-Wolff, Seemüller F, Obermeier M, Messer T, Laux G, Pfeiffer H, Naber D, Schmidt LG, Gaebel W, Klosterkötter J, Heuser I, Maier W, Lemke MR, Rüther E, Buchkremer G, Gastpar M, Jäger M, Möller HJ, Riedel M (2010) Response and remission of subjective well-being in patients suffering from schizophrenia spectrum disorders. Eur Psychiatry Apr 30 (epub)
Zeugmann S, Quante A, Marx N, Koenig W, Heuser I, Schwarzer R, Anghelescu I (2010) Inflammatory markers in 70 depressed inpatients with and without the metabolic syndrome. J Clin Psychiatry Feb 9 (epub)
Schennach-Wolff R, Jäger M, Seemüller F, Obermeier M, Schmauss M, Laux G, Pfeiffer H, Naber D, Schmidt LG, Gaebel W, Klosterkötter J, Heuser I, Maier W, Lemke MR, Rüther E, Klingberg S, Gastpar M, Möller HJ, Riedel M (2009) Outcome of suicidal patients with schizophrenia. Results from a naturalistic study. Acta Psychiatr Scand Oct 30 (epub)
Jäger M, Riedel M, Obermeier M, Schennach-Wolff R, Seemüller F, Messer T, Laux G, Pfeiffer H, Naber D, Schmidt LG, Gaebel W, Klosterkötter J, Heuser I, Kühn K-U, Lemke MR, Rüther E, Klingberg S, Gastpar M, Bottlender R, Möller H-J (2010) Time course of antipsychotic treatment response in schizophrenia: Results from a naturalistic study in 280 patients. Schizophr Res 118:183-8
Kronenberg G, Gertz K, Baldinger T, Eckart S, Ji S, Yildirim F, Heuser I, Schröck H, Hörtnagl H, Djoufack PC, Jüttner R, Hellweg R, Fink KB, Endres M (2010) Impact of actin filament stabilization on adult hippocampal and olfactory bulb neurogenesis. J Neurosci 30:3419-31
Lemke H, de Castro AG, Schlattmann P, Heuser I, Neu P (2010) Cerebrovascular reactivity over time-course – from major depressive disorder to remission. J Psychiatr Res 44:132-6
Lewczuk P, Kornhuber J, Vanmechelen E, Peters O, Heuser I, Maier W, Jessen F, Bürger K, Hampel H, Frölich L, Henn F, Falkai P, Rüther E, Jahn H, Luckhaus C, Perneczky R, Schmidtke K, Schröder J, Kessler H, Pantel J, Gertz HJ, Vanderstichele H, de Meyer G, Shapiro F, Wolf S, Bibl M, Wiltfang J (2010) Amyloid beta peptides in plasma in early diagnosis of Alzheimer’s disease: A multicenter study with multiplexing. Exp Neurol 223:366-70
Lewczuk P, Kamrowski-Kruck H, Peters O, Heuser I, Jessen F, Popp J, Bürger K, Hampel H, Frölich L, Wolf S, Prinz B, Jahn H, Luckhaus C, Perneczky R, Hüll M, Schröder J, Kessler H, Pantel J, Gertz HJ, Klafki HW, Kölsch H, Reulbach U, Esselmann H, Maler JM, Bibl M, Kornhuber J, Wiltfang J (2010) Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study. Mol Psychiatry 15:138-45
Reichmann, H, Deuschl G, Riedel O, Spottke, A, Förstl H, Henn F, Heuser I, Oertel W, Riederer P, Trenkwalder C, Dodel R, Wittchen H-U (2010) Die “German Study on the Epidemiology of Parkinson’s Disease with Dementia” (GEPAD): mehr als nur Parkinson. MMW Fortschr. Med. Originalien I (152. Jg.) S.1-6
Riedel O, Heuser I, Klotsche J, Dodel R, Wittchen H-U (2010) Occurence risk and structure of depression in Parkinsons disease with and without dementia: Results from the GEPAD study. J Geriatr Psychiatry Neurol 23:27-34
Ritter K, Röpke S, Merkl A, Heuser I, Fydrich T, Lammers CH (2010) Komorbiditäten bei Patienten mit einer Narzisstischen Persönlichkeitsstörung im Vergleich zu Patienten mit einer Borderline-Persönlichkeitsstörung. Psychother Psych Med 60:14-24
Seemüller F, Riedel M, Obermeier M, Bauer M, Adli M, Mundt C, Holsboer F, Brieger P, Laux G, Bender W, Heuser I, Zeiler J, Gaebel W, Dichgans E, Bottländer R, Musil R, Möller HJ. Outcomes of 1014 naturalistic treated inpatients with major depressive episode (2010) Eur Neuropsychopharmacol 20:346-55
Jäger M, Schmauß M, Laux G, Pfeiffer H, Naber D, Schmidt LG, Gaebel W, Klosterkötter J, Heuser I, Maier W, Lemke MR, Degner D, Buchkremer G, Gastpar M, Möller HJ, Riedel M (2009) Early improvement as a predictor of remission and response in schizophrenia: Results from a naturalistic study. Eur Psychiatry 24:501-6
Klafki HW, Lewczuk P, Kamrowski-Kruck H, Maler JM, Müller K, Peters O, Heuser I, Jessen F, Popp J, Frölich L, Wolf S, Prinz B, Luckhaus C, Schröder J, Pantel J, Gertz HJ, Kölsch H, Müller BW, Esselmann H, Bibl M, Kornhuber J, Wiltfang J (2009) Measurement of ERK 1/2 in CSF from Patients with Neuropsychiatric Disorders and Evidence for the Presence of the Activated Form. J Alzheimers Dis 18:613-22
Kork F, Holthues J, Hellweg R, Jankowski V, Tepel M, Ohring R, Heuser I, Bierbrauer J, Peters O, Schlattmann P, Zidek W, Jankowski J (2009) A possible new diagnostic biomarker in early diagnosis of Alzheimer’s disease. Curr Alzheimer Res 6:519-24
Schennach-Wolff R, Jäger M, Seemüller F, Obermeier M, Messer T, Laux G, Pfeiffer H, Naber D, Schmidt LG, Gaebel W, Klosterkötter J, Heuser I, Maier W, Lemke MR, Rüther E, Klingberg S, Gastpar M, Möller HJ, Riedel M. (2009) Attitude towards adherence in patients with schizophrenia at discharge. J Psychiatr Res 43:1294-1
Schennach-Wolff R, Jäger M, Seemüller F, Obermeier M, Messer T, Laux G, Pfeiffer H, Naber D, Schmidt LG, Gaebel W, Huff W, Heuser I, Maier W, Lemke MR, Rüther E, Buchkremer G, Gastpar M, Möller HJ, Riedel M. (2009) Defining and predicting functional outcome in schizophrenia and schizophrenia spectrum disorders. Schizophr Res 113:210-7
Kronenberg G, Kirste I, Inta D, Chourbaji S, Heuser I, Endres M, Gass P (2009) Reduced hippocampal neurogenesis in the GR(+/-) genetic mouse model of depression. Eur Arch Clin Neurosci 259:499-504
Kronenberg G, Tebartz van Elst L, Regen F, Deuschle M, Heuser I, Colla M. (2009) Reduced amygdala volume in newly admitted psychiatric in-patients with unipolar major depression. J Psychiatr Res 43:1112-7
Harold D, Abraham R, …, Heuser I … et al (2009) Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease, and shows evidence for additional susceptibility genes. Nature genet 41:1088-93
Ziegenhorn AA, Röpke S, Schommer NC, Merkl A, Danker-Hopfe H, Perschel FH, Heuser I, Anghelescu IG, Lammers CH (2009) Clonidine improves hyperarousal in borderline personality disorder with or without comorbid posttraumatic stress disorder: a randomized, double-blind, placebo-controlled trial. J Clin Psychpharmacol 29:170-3
Schennach-Wolff R, Jäger M, Seemüller F, Obermeier M, Schmauss M, Laux G, Pfeiffer H, Naber D, Schmidt LG, Gaebel W, Klosterkötter J, Heuser I, Maier W, Lemke MR, Rüther E, Klingberg S, Gastpar M, Möller HJ, Riedel M (2009) Outcome of suicidal patients with schizophrenia. Results from a naturalistic study. Acta Psychiatr Scand Oct 30 (epub)
Kornhuber J, Schmidtke K, Frölich L, Perneczky R, Wolf S, Hampel H, Jessen F, Heuser I, Peters O, Weih M, Jahn H, Luckhaus C, Hüll M, Gertz H-J, Schröder J, Pantel J, Rienhoff O, Seuchter SA, Rüther E, Henn F, Maier W, Wiltfang J (2009) Early and differential diagnosis of dementia and mild cognitive impairment: design and cohort baseline characteristics of the German –Dementia Competence Network. Dement Geriatr Cogn Disord 27:404-17
Kölsch H, Jessen F, Wiltfang J, Lewczuk P, Dichgans M, Teipel SJ, Kornhuber J, Frölich L, Heuser I, Peters O, Wiese B, Kaduszkiewicz H, van den Bussche H, Hüll M, Kurz A, Rüther E, Henn FA, Maier W (2009) Association of SORL1 gene variants with Alzheimer's disease. Brain Research 1264:1-6
Seemüller F, Riedel M, Obermeier M, Bauer M, Adli M, Mundt C, Holsboer F, Marneros A, Laux G, Bender W, Heuser I, Zeiler J, Jäger M, Henkel V, Möller HJ (2009) The controversial link between antidepressants and suicidality risks in adults: data from a naturalistic study on a large sample of in-patients with a major depressive episode. Int J Neuropsychopharmacol 12:181-9
Weber-Hamann B, Blum WF, Kratzsch J, Gilles M, Heuser I, Deuschle M (2009) Insulin-like growth factor-I (IGF-I) serum concentrations in depressed patients: relationship to saliva cortisol and changes during antidepressant treatment. Pharmacopsychiatry 42:23-8
Merkl A, Heuser I, Bajbouj M (2009) Antidepressant electroconvulsive therapy: Mechanism of action, recent advances and limitations. Exp Neurol May (epub)
Henkel V, Seemüller F, Obermeier M, Adli M, Bauer M, Mundt C, Brieger P, Laux G, Bender W, Heuser I, Zeiler J, Gaebel W, Mayer A, Möller H-J, Riedel M (2008). Does early improvement triggered by antidepressants predict response/remission? – Analysis of data from a naturalistic study on a large sample of inpatients with major depression. J Affect Disord Nov 21 (Epub)
Lewczuk P, Kamrowski-Kruck H, Peters O, Heuser I, Jessen F, Popp J, Bürger K, Hampel H, Frölich L, Wolf S, Prinz B, Jahn H, Luckhaus C, Perneczky R, Hüll M, Schröder J, Kessler H, Pantel J, Gertz HJ, Klafki HW, Kölsch H, Reulbach U, Esselmann H, Maler JM, Bibl M, Kornhuber J, Wiltfang J (2008) Soluble amyloid precursor proteins in the cerebrospinal fluid as novel potential biomarkers of Alzheimer's disease: a multicenter study. Mol Psychiatry Jul 29 (Epub)
Kronenberg G, Ende G, Alm B, Deuschle M, Heuser I, Colla M (2008) Increased NAA and reduced choline levels in the anterior cingulum following chronic methylphenidate: a spectroscopic test-retest study in adult ADHD. Eur Arch Psychiatry Clin Neurosci 258:446-50
Möller HJ, Riedel M, Jäger M, Wickelmaier F, Maier W, Kühn KU, Buchkremer G, Heuser I, Klosterkötter J, Gastpar M, Braus DF, Schlösser R, Schneider F, Ohmann C, Riesbeck, Gaebel W (2008) Short-term treatment with risperidone or haloperidol in first-episode schizophrenia: 8-week results of a randomized controlled trial within the German Research Network on Schizophrenia. Int J Neuropsychopharmacol 11:985-97
Lewitzka U, Müller-Oerlinghausen B, Felber W, Brunner J, Hawellek B, Rujescu D, Ising M, Lauterbach E, Broocks A, Bondy B, Rao ML, Frahnert C, Heuser I, Hohagen F, Maier W, Bronisch T (2008) Is MAO-B activity in platelets associated with the occurrence of suicidality and behavioural personality traits in depressed patients? Acta Psychiatr Scand 117:41-9
Hellweg R, Ziegenhorn A, Heuser I, Deuschle M (2008) Serum concentrations of nerve growth factor and brain-derived neurotrophic factor in depressed patients before and after antidepressant treatment. Pharmacopsychiatry 41:66‑71
Kölsch H, Jessen F, Wiltfang J, Lewczuk P, Dichgans M, Kornhuber J, Frölich L, Heuser I, Peters O, Schulz JB, Schwab SG, Maier W (2008) Influence of SORL1 gene variants: association with CSF amyloid-beta products in probable Alzheimer's disease. Neurosci Lett 440:68-71
Jakob F, Brakemeier EL, Schommer NC, Quante A, Merkl A, Danker-Hopfe H, Anghelescu I, Heuser I, Bajbouj M (2008) Ultrahigh frequency repetitive transcranial magnetic stimulation in unipolar depression. J Clin Psychopharmacol 28:474-6
Seemüller F, Riedel M, Wickelmaier F, Adli M, Mundt C, Marneros A, Laux G, Bender W, Heuser I, Zeiler J, Gaebel W, Jäger M, Möller HJ, Henkel V (2008) Atypical symptoms in hospitalised patients with major depressive episode: frequency, clinical characteristics, and internal validity. J Affect Disord 108:271-8
Röpke S, Merkl A, Dams A, Ziegenhorn A, Anghelescu IG, Heuser I, Lammers CH (2008) Preliminary evidence of improvement of depressive symptoms but not impulsivity in Cluster B personality disorder patients treated with Quetiapine: an open label trial. Pharmacopsychiatry 41:176-81
Colla M, Ende G, Alm B, Deuschle M, Heuser I, Kronenberg G (2008) Cognitive MR spectroscopy of anterior cingulate cortex in ADHD: elevated choline signal correlates with slowed hit reaction times. J Psychiatr Res 42:587-95
De Castro AG, Bajbouj M, Schlattmann P, Lemke H, Heuser I, Neu P (2008) Cerebrovascular reactivity in depressed patients without vascular risk factors. J Psychiatr Res 42:78-82
Schlaepfer TE, Frick C, Zobel A, Maier W, Heuser I, Bajbouj M, O'Keane V, Corcoran C, Adolfsson R, Trimble M, Rau H, Hoff HJ, Padberg F, Müller-Siecheneder F, Audenaert K, Van den Abbeele D, Matthews K, Christmas D, Stanga Z, Hasdemir M (2008) Vagus nerve stimulation for depression: efficacy and safety in a European study. Psychol Med 38:651-61
Seemüller F, Riedel M, Wickelmaier F, Adli M, Mundt C, Marneros A, Laux G, Bender W, Heuser I, Zeiler J, Gaebel W, Jäger M, Möller HJ, Henkel V (2008) Atypical symptoms in hospitalised patients with major depressive episode: frequency, clinical characteristics, and internal validity. J Affect Disord 108:271-8
Hornung OP, Regen F, Warnstedt C, Anghelescu I, Danker-Hopfe H, Heuser I, Lammers C-H (2008) Declarative and procedural memory consolidation during sleep in patients with borderline personality disorder. J Psychiatr Res 42:653-8
Hornung OP, Regen F, Danker-Hopfe H, Heuser I, Anghelescu I (2008) Sleep-related memory consolidation in depression: an emerging field of research. Depress Anxiety 25:E163-5
Jäger M, Riedel M, Messer T, Laux G, Pfeiffer H, Naber D, Schmidt LG, Gaebel W, Huff W, Heuser I, Kühn KW, Lemke MR, Rüther E, Buchkremer G, Gastpar M, Bottlender R, Strauss A, Möller HJ (2007) Psychopathological characteristics and treatment response of first episode compared with multiple episode schizophrenic disorders. Eur Arch Psychiatry Clin Neurosci 257:47-53
Dams A, Schommer N, Röpke S, Heuser I, Lammers CH (2007) Skill training and the post-treatment efficacy of dialectic behavior therapy six month after discharge of the hospital. Psychother Psychosom Med Psychol 57:19-24
King JA, Colla M, Brass M, Heuser I, von Cramon DY (2007) Inefficient cognitive control in adult ADHD: evidence from a trial-by-trial Stoop test and cued task switching performance. Behav Brain Funct 3:42
Riedel O, Dodel R, Wittchen H-U, Deuschl G, Foerstl H, Henn F, Heuser I, Oertel W, Reichmann H, Riederer P, Trenkwalder C. Wie beurteilen Ärzte die Häufigkeit demenzieller, depressiver und psychotischer Syndrome bei Patienten mit Parkinsonerkrankungen? (submitted)
Hornung OP, Regen F, Warnstedt C, Anghelescu I, Danker-Hopfe H, Heuser I, Lammers C-H (2008). Declarative and procedural memory consolidation during sleep in patients with borderline personality disorder. Journal of Psychiatric Research 42:653-8
Jaeger M, Riedel M, Schmauss M, Laux G, Pfeiffer H, Naber D, Gaebel W, Klosterkoetter J, Heuser I, Kuehn K-U, Lemke MR, Rüther E, Buchkremer G, Gastpar M, Bottlender R, Strauss A, Moeller H-J (2007). Prediction of symptom remission in Schizophrenia during inpatient treatment. World J Biol Psychiatry Sep 12:1-9 (Epub)
Jaeger M, Riedel M, Schmauss M, Pfeiffer H, Laux G, Naber D, Gaebel W, Huff W, Schmidt LG, Heuser I, Buchkremer G, Kuehn K-U, Rüther E, Hoff P, Gastpar M, Bottlender R, Strauss A, Moeller H-J (2008). Depression during an acute episode of schizophrenia or schizophreniform disorder and its impact on treatment response. Psychiatry Res 158:297-305
Riedel O, Klotsche J, Spottke A, Deuschl G, Förstl H, Henn F, Heuser I, Oertel W, Reichmann H, Riederer P, Trenkwalder C, Dodel R, Wittchen H-U (2008). Cognitive impairment in 873 patients with idiopathic Parkinson’s Disease: Results from the German Study on Epidemiology of Parkinson’s Disease with Dementia (GEPAD). J Neurol 255:255-64
Dams A, Schommer N, Röpke S, Heuser I, Lammers CH (2007) Skill training and the post-treatment efficacy of dialectic behavior therapy six month after discharge of the hospital. Psychother Psychosom Med Psychol 57:19-24
Halbreich U, Backstrom T, Eriksson E, O’Brien S, Calil H, Ceskova E, Dennerstein L, Douki S, Freeman E, Genazzani A, Heuser I, Kadri N, Rapkin A, Steiner M, Wittchen HU, Yonkers K (2007) Clinical diagnostic critieria for premenstrual syndrome and guidelines for their quantification for research studies. Gynecol Endocrinol 23:123-30
Weber-Hamann B, Kratzsch J, Kopf D, Lederbogen F, Gilles M, Heuser I, Deuschle M (2007) Resistin and adiponectin in major depression: the association with free cortisol and effects of antidepressant treatment. J Psychiatr Res 41:344-50
Weber-Hamann B, Gilles M, Lederbogen F, Heuser I, Deuschle M (2006) Improved insulin sensitivity in 80 nondiabetic patients with MDD after clinical remission in a double-blind, randomized trial of amitriptyline and paroxetine. J Clin Psychiatry 67:1856-61
Lauterbach E, Brunner J, Hawellek B, Lewitzka U, Ising M, Bondy B, Rao ML, Frahnert C, Rujescu D, Müller-Oerlinghausen B, Schley J, Heuser I, Maier W, Hohagen F, Felber W, Bronisch T (2006) Platelet 5-HT2A receptor binding and tryptophan availability in depression are not associated with recent history of suicide attempts but with personality traits characteristic for suicidal behavior. J Affect Disord 91:57-62
Froelich L, Heuser I, Wellek S (2006) Zur klinischen Relevanz von Cholinesterase-Inhibitoren bei Alzheimer Krankheit: Eine klinische und biometrische Kritik der AD2000-Studie. psychoneuro 32:32-7
Bajbouj M, Lisanby SH, Lang UE, Danker-Hopfe H, Heuser I, Neu P (2006) Evidence for impaired cortical inhibition in patients with unipolar major depression. Biol Psychiatry. 59:395-400
Bajbouj M, Lang UE, Niehaus L, Hellen FE, Heuser I, Neu P (2006). Effects of right unilateral electroconvulsive therapy on motor cortical excitability in depressive patients. J Psychiatr Res 40:322-7
Bajbouj M, Danker-Hopfe H, Heuser I, Anghelescu I (2006) Long-term outcome of vagus nerve stimulation in rapid-cycling bipolar disorder. J Clin Psychiatry 67:837-8
Hornung OP, Regen F, Schredl M, Heuser I, Danker-Hopfe H (2006) Manipulating REM sleep in older adults by selective REM sleep deprivation and physiological as well as pharmacological REM sleep augmentation methods. Exp Neurol 197:486-94
Jaeger M, Riedel M, Messer T, Laux G, Pfeiffer H, Naber D, Schmidt LG, Gaebel W, Huff W, Heuser I, Kuehn K-W, Lemke MR, Ruether E, Buchkremer G, Gastpar M, Bottlender R, Strauss A, Moeller H-J (2006) Psychopathological characteristics and treatment response of first episode compared with multiple episode schizophrenic disorders. Eur Arch Psychiatry Clin Neurosci Oct 10: Epub ahead of print
Neu P, Schwertfeger N, Schlattmann P, Heuser I, Berman RM (2006) Cerebrovascular reactivity following administration of mirtazapine in healthy probands – a randomized, placebo controlled double-blind clinical study. J Psychiatr Res 40:349-52
De Castro AG, Bajbouj M, Schlattmann P, Lemke H, Heuser I, Neu P (2006) Cerebrovascular reactivity in depressed patients without vascular risk factors. J Psychiatr Res Nov 17: Epub ahead of print
Schwertfeger N, Neu P, Schlattmann P, Lemke H, Heuser I, Bajbouj M (2006) Cerebrovascular reactivity over time course in healthy subjects. J Neurol Sci 249:135-9
Gilles M, Deuschle M, Kellner S, Shams M, Krumm B, Härtter S, Heuser I, Hiemke C (2005) Paroxetine serum concentrations in depressed patients and response to treatment. Pharmacopsychiatry 38:118-21
Regen F, Merkl A, Heuser I, Dettling M, Anghelescu I (2005) Diabetes and depression. Dtsch Med Wochenschr 130:1097-102
Neu P, Heuser I, Bajbouj M (2005) Cerebral blood flow during vagus nerve stimulation – a transcranial Doppler study. Neuropsychobiology 51:265-8
Deuschle M, Sander P, Herpfer I, Fiebich BL, Heuser I, Lieb K (2005) Substance P in serum and cerebrospinal fluid of depressed patients: no effect of antidepressant treatment. Psychiatry Res 136:1-6
Weber-Hamann B, Kopf D, Lederbogen F, Gilles M, Heuser I, Colla M, Deuschle M (2005) Activity of the hypothalamus-pituitary-adrenal system and oral glucose tolerance in depressed patients. Neuroendocrinology 81:200-4
Bronisch T, Brunner J, Bondy B, Rujescu D., Bishof G, Heuser I, Mueller-Oerlinghausen B, Hawellek B, Maier W, Rao ML, Felber W, Lewitzka U, Oehler J, Broocks A, Hohagen F, Lauterbach E (2005) A multicenter study about neurobiology of suicidal behaviour: design, development, and preliminary results. Arch Suicide Res 9:19-26
Lauterbach E, Ahrens B, Felber W, Oerlinghausen BM, Kilb B, Bischof G, Heuser I, Werner P, Hawellek B, Maier W, Lewitzka U, Pogarell O, Hegerl U, Bronisch T, Richter K, NIklweski G, Broocks A, Hohagen F (2005) Suicide prevention by lithium SUPLI – challenges of a multi-center prospective study. Arch Suicide Res 9:27-34
Froelich L, Gertz HJ, Heun R, Heuser I, Jendroska K, Kornhuber J, Kurz A, Mueller-Thomsen T, Ries F, Waechtler C, Metz M, Goebel C (2004) Donepezil for Alzheimer’s disease in clinical practice – the DONALD study. Dement Geriatr Cogn Disord 18:37-43
Kopf D, Westphal S, Luley CW, Ritter S, Gilles M, Weber-Hamann B, Lederbogen F, Lehnert H, Henn F, Heuser I, Deuschle M (2004) Lipid metabolism and insulin resistance in depressed patients: significance of weight, hypercortisolism and antidepressant treatment. J Clin Psychopharmacol 24:527-31
Schmitt B, Bernhardt T, Moeller HJ, Heuser I, Froelich L (2004) Combination therapy in Alzheimer’s disease: a review of current evidence. CNS drugs 18:827-44
Hock C, Maddalena A, Rasching A, Müller-Spahn F, Eschweiler G, Hager K, Heuser I, Hampel H, Müller-Thomsen T, Oertel W, Wienrich M, Signorelli A, Gonzalez-Agosti, C, Nitsch RM (2003) Treatment with the selective muscarinic m1 agonist talsaclidine decreases cerebrospinal fluid levels of A beta 42 in patients with Alzheimer’s disease. Amyloid 10:1-6
Lederbogen F, Gernoth C, Hamann B, Kniest A, Heuser I, Deuschle M (2003) Circadian blood pressure regulation in hospitalized depressed patients and non-depressed comparison subjects. Blood Press Monit 8:71-6
Lederbogen F, Schredl M, Weber-Hamann B, Kniest A, Heuser I (2003) Effect of ambulatory blood pressure measurement on sleep in patients with a major depressive episode. Blood Press Monit 8:187-90
Lederbogen F, Horer E, Hellweg R, Heuser I, Deuschle M (2003) Platelet counts in depressed patients treated with amitriptyline or paroxetine. Eur Psychiatry 18:89-91
Henning O, Niedermaier N, Kniest A, Heuser I, Deuschle M (2002) Amitriptyline and paroxetine: effects upon peripheral nervous system (PNS). J Clin Psychopharmacol 22:229-30
Kniest A, Wiesenberg C, Weber B, Colla M, Heuser I, Deuschle M (2001) The glutamate antagonist riluzole and ist effects upon basal and stress-induces activity of the human hypothalamus-pituitary-adrenocortical (HPA) system in elderly subjects. Neuropsychobiology 43:91-5
Lederbogen F, Weber B, Colla M, Heuser I, Deuschle M, Dempfle CE (2001) Antidepressant treatment and global tests of coagulation and fibrinolysis. J Clin Psychiatry 62:130
Lederbogen F, Gernoth C, Weber B, Colla M, Kniest A, Heuser I, Deuschle M (2001) Antidepressive treatment with amitriptyline and paroxetine: comparable effects upon heart rate variability. J Clin Psychopharmacol 21:238-9
Lederbogen F, Gilles M, Maras A, Hamann B, Colla M, Heuser I, Deuschle M (2001) Increased platelet aggregability in major depression? Psychiatry Res 102:255-61
Hinze-Selch D, Deuschle M, Weber B, Heuser I, Pollmächer T (2000) Effect of coadministration on blood cell counts, plasma levels of cytokines and body weight. Psychopharmacology 149:163-9
Hock C, Maddalena A, Heuser I, Naber D, Oertel W, von der Kammer H, Wienrich M, Raschig A, Deng M, Growdon JH, Nitsch RM (2000) Treatment with the selective muscarinic agonist Talsaclidine drcreases cerebrospinal fluid levels of total amyloid -peptide in Patients with Alzheimer's disease. Ann NY Acad Sci 920:285-91
Lederbogen F, Weber B, Colla M, Heuser I, Deuschle M (1999) Endothelin-1 plasma concentrations in depressed patients and healthy controls. Neuropsychobiology 40:121-3
Deuschle M, Bode Liv, Heuser I, Schmider J, Ludwig H (1998) Borna disease virus proteins in cerebrospinal fluid of patients with recurrent major depression and multiple sclerosis. Lancet 352:1828-9
Holsboer F, Spengler D, Heuser I (1992) The role of corticotropin-releasing hormone in the pathogenesis of Cushing's disease, anorexia nervosa, alcoholism, affective disorders and dementia. Prog Brain Res 93:385-417
Mouradian MM, Blin J, Giuffra M, Heuser IJ, Baronti F, Ownby J, Chase TN (1991) Somatostatin replacement therapy for Alzheimer dementia. Ann Neurol 30:610-3
Mouradian MM, Heuser IJE, Baronti F, Giuffra M, Conant K, Davis TL, Chase TN (1991) Comparison of the clinical pharmacology of (-)NPA and levodopa in Parkinson's disease. J Neurol Neurosurg Psychiatry 54:401-5
Buller R, Maier W, Heuser I, Frommberger U (1990) Panikattacken und Vermeidungsverhalten. Psychiatr Prax 17:41-6
Mouradian MM, Heuser IJE, Baronti F, Chase TN (1990) Modification of central dopaminergic mechanisms by continuous levodopa therapy for advanced Parkinson's disease. Ann Neurol 27:18-23
Stein MB, Heuser IJ, Juncos JL, Uhde TW (1990) Anxiety disorders in patients with Parkinson’s disease. Am J Psychiatry 147:217-20
von Bardeleben U, Heuser I, Holsboer F (1989) Human CRH stimulation response during acute withdrawal and after medium-term abstention from alcohol abuse. Psychoneuroendocrinology 14:441-9
Chase TN, Baronti F, Fabbrini G, Heuser IJ, Juncos JL, Mouradian MM (1989) Rationale for continuous dopaminomimetic therapy of Parkinson’s disease. Neurology 39:7-10
Maier W, Philipp M, Schlegel S, Heuser I, Wiedemann K, Benkert O (1989) Diagnostic determinants of response to treatment with tricyclic antidepressants: a polydiagnostic approach. Psychiatry Res 30:83-93
Mouradian MM, Heuser IJ, Baronti F, Fabbrini G, Juncos JL, Chase TN (1989) Pathogenesis of dyskinesias in Parkinson's disease. Ann Neurol 25:523-6
Mouradian MM, Heyes MP, Pan JB, Heuser IJ, Markey SP, Chase TN (1989) No changes in central quinolinic acid levels in Alzheimer's disease. Neurosci Lett 105: 233-8
Schlegel S, Maier W, Philipp M, Heuser I, Kretzschmar K, Benkert O (1989) CT in depression: Associations between ventricular size and psychopathology. Psychiatry Res 29:221-30
Maier W, Buller R, Philipp M, Heuser I (1988) The Hamilton Anxiety Scale: reliability, validity and sensitivity to change in anxiety and depressive disorders. J Affective Disord 14:61-8
Maier W, Heuser I, Philipp M, Frommberger V, Demuth W (1988) Improving depression severity assessment. II. Content, concurrent and external validity of three observers depression scales. J Psychiatr Res 22:13-9
Maier W, Heuser I, Philipp M, Schlegel S, Benkert O (1988) Diagnostic determinants of short-term spontaneous course of major depression. Psychiatry Res 23:117-8
Maier W, Philipp M, Heuser I, Schlegel S, Buller R, Wetzel H (1988) Improving depression severity assessment. I. Reliability, internal validity and sensitivity to change of three observers scales. J Psychiatr Res 22:3-12
Schlegel S, Maier W, Philipp M, Heuser I, Aldenhoff J (1988) The association between psychopathological aspects and CT measurements in affective disorders. Pharmacopsychiatry 21:416-7
Wetzel H, Heuser I, Benkert O (1988) Benzodiazepines for catatonic symptoms, stupor, and mutism. Pharmacopsychiatry 21:394-5 (short communication)
Wetzel H, Heuser IJ, Benkert O (1987) Treatment of depressive symptoms with lorazepam and reoccurrence of symptoms after application of the BZ-antagonist Ro 15-1788. J Nerv Ment Dis 175:240-2
Wetzel H, Heuser IJ, Benkert O (1987) Stupor and affective state: alleviation of psychomotor disturbances by lorazepam and recurrence of symptoms after Ro 15-1788. J Nerv Ment Dis, 174:240-2

Buchbeiträge

Heuser, I (2009) Psychopharmaka zur Leistungsverbesserung, Tagungs-dokumentation Der steuerbare Mensch? Über Einblicke und Eingriffe in unser Gehirn. Jahrestagung des Deutschen Ethikrates 2009, pp. 49-55
Heuser I, Anghelescu I (2008) Antidementiva. In: Holsboer F, Gründer G, Benkert O (Eds.) Handbuch der Psychopharmakotherapie. Springer Verlag Heidelberg, pp. 643-65
Anghelescu I, Heuser I, (2008) Psychostimulanzien. In: Holsboer F, Gründer G, Benkert O (Eds.) Handbuch der Psychopharmakotherapie. Springer Verlag Heidelberg, pp. 701-8
Colla M, Heuser I (2008) Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung im Erwachsenenalter. In: Holsboer F, Gründer G, Benkert O (Eds.) Handbuch der Psychopharmakotherapie. Springer Verlag Heidelberg, pp. 1023-32
Anghelescu I, Lange-Asschenfeldt, Heuser I, (2008) Pharmakotherapie psychiatrischer Notfallsituationen. In: Holsboer F, Gründer G, Benkert O (Eds.) Handbuch der Psychopharmakotherapie. Springer Verlag Heidelberg, pp. 1049-58
Schommer NC, Heuser I (2007) DEX-CRH Test. In: Fink G (Ed.) Encyclopedia of Stress, Four-Volume Set, Second Edition, Elsevier, pp. 784-7
Schommer NC, Heuser I (2006) Stress Systems in Aging – Cognitions and Dementia. In: Arnetz BB, Ekman R (Ed.) Stress in Health and Disease. Wiley VCH, pp. 366-83
Heuser I, Anghelescu I (2003) Kognitives Altern und Demenz-Erkrankungen. UNI-MED Verlag Bremen, First Edition
Anghelescu I, Heuser I (2003) Psychostimulants. In: Rosenthal W, Offermanns S (Eds.) Encyclopedic reference of molecular pharmacology. Springer-Verlag Heidelberg, pp. 775-81
Heuser I (2002) Psychosomatik. In: Ralf Schwarzer, Matthias Jerusalem und Hannelore Weber (Eds.) Gesundheitspsychologie von A bis Z. Hogrefe Verlag Göttingen, pp. 420-3
Heuser I (2001) Depression, metabolisches Syndrom und kardiovaskuläre Morbidität. In: Rohde A und Riecher-Rössler A (Eds.) Psychische Erkrankungen bei Frauen. S. Roderer Verlag, Regensburg, pp. 329-31
Heuser I (2000) Neurosteroids. In: Halbreich U, Montgomery S (Eds.) Pharmacotherapy for Mood, Anxiety, and Cognitive Disorders. Bio Behavioral Programm
Heuser I (2000) Depressive Erkrankungen im Alter. In: Nikolaus T (Eds.) Klinische Geriatrie. Springer-Verlag, Berlin, Heidelberg, New-York, pp. 441-9
Heuser I (1999) Psychoneuroendokrinologie. In: Helmchen H, Henn FA, Lauter H (Eds.) Psychiatrie der Gegenwart, Band 1, Springer-Verlag, Berlin, Heidelberg, New York, Barcelona, Hongkong, London, Mailand, Paris, Singapur, Tokio, pp. 235-48
Heuser I (1997) Psychiatrische Notfälle. In: Dick WF, Lemburg P, Schuster H-P (Eds.) Aktuelle Notfallmedizin in der Praxis: Handbuch zu Notfällen und Notfallsituationen in der Praxis und Klinik. Spitta, Balingen
Heuser I (1995) Age-related changes in psychoneuroendocrinological function. In: Scherbaum WA, Rossmanith WG (Eds.) The Endocrinology of Aging. Walter de Gruyter, Berlin, New York, pp. 15-23
Heuser I (1995) Veränderungen des hypophysär-adrenalen Systems im Alter und bei wiederholten Belastungen. In: Allolio B, Benker G, Schulte HM (Eds.) Nebenniere und Streß - Von den Grundlagen zur Klinik. Schattauer, Stuttgart, New York, pp. 159-66
Gotthardt U, Heuser I (1995) Neuroendokrinologische Forschung in der Psychiatrie. In: Lieb K, Riemann D, Berger M (Eds.) Biologisch-Psychiatrische Forschung - Ein Überblick. G. Fischer, Stuttgart, Jena, New York, pp. 43-70
Wittchen H-U, Möller H-J, Vossen A, Hautzinger M, Kasper S, Heuser I (1995) Depression - Wege aus der Krankheit. HEXAL-Ratgeber. Karger, Basel, Paris, New York
Heuser I (1993) Endokrine Psychosyndrome. In: Schüttler R (Eds.) Organische Psychosyndrome. Springer, Berlin, Heidelberg, New York, London, Paris, Tokyo, Hong Kong, Barcelona, Budapest, pp. 53-67
Heuser I, Möller A (1992) Einzelne psychopathologische Symptome. Depression. In: Möller A, Fröscher W (Eds.) Psychische Störungen bei Epilepsie. Thieme, Stuttgart, New York, pp. 37-44
Heuser I, Holsboer F (1991) Pathophysiology of hypothalamic-pituitary-adrenal-axis function in depression. In: Ansseau M, von Frenckell R, Franck G (Eds.) Biological Markers of Depression: State of the Art. Elsevier, Amsterdam, pp. 13-8
Heuser IJ, Litvan I, Juncos JL, Khan I, Kleing MA, Chase TN, Gold PW (1988) Cortisol baseline secretion and memory performance in patients with dementia of the Alzheimer's type. In: Agnoli A, Cahn J, Lassen N, Mayeux R (eds.) Senile Dementias. II International Symposium. John Libbey Eurotext, Paris, pp. 351-3
Holsboer F, von Bardeleben U, Heuser IJ, Steiger A (1988) Human corticotropin-releasing hormone challenge tests in depression. In: Schatzberg AF, Nemeroff Ch (Eds.) Hypothalamic-Pituitary-Adrenocortical Physiology and Pathophysiology. Raven Press, New York, pp. 79-100
Holsboer F, von Bardeleben U, Buller R, Heuser IJ, Steiger A (1987) Stimulation response to corticotropin-releasing hormone (CRH) in patients with depression, alcoholism and panic disorders. In: Hormones and Metabolic Research, Vol. 19. Thieme, Stuttgart New-York, pp. 80-8
Heuser IJ (1986) Notfälle aus der Psychiatrie. In: Ahnefeld FW, Dick W, Kilian J, Schuster H-P (Eds.) Notfallmedizin. Springer, Berlin, Heidelberg, New York, London, Paris, Tokyo, pp. 319-23